Overview of the Hepatitis B Epidemiology and Vaccination among Healthcare Workers
DOI:
https://doi.org/10.59992/IJSR.2023.v2n11p20الكلمات المفتاحية:
Hepatitis، Vaccine، Epidemiology، Healthcare Workers، Prevalenceالملخص
Introduction: Healthcare workers (HCWs) who are at high risk for HBV infection, have been recommended to receive the HB vaccine for over 20 years. This review aimed to highlight the enablers and obstacles facing the universal coverage of hepatitis B epidemiology and vaccination among healthcare workers.
Methods: A search was conducted using the following terms related to hepatitis B, vaccination, and healthcare workers in Africa: hepatitis B, hepatitis B virus, vaccination, immunization, healthcare workers, health workers, and health personnel. This review included cross-sectional, case-control, and cohort studies. Studies in English or French from any location were selected. A search was conducted for articles published from 1970 to 2022 in PubMed and the Excerpta Medica Database (Embase) using search terms related to hepatitis B and healthcare workers.
Results: This study analyzed 25 cross-sectional studies on healthcare workers (HCWs) in African countries to determine the prevalence of hepatitis B vaccination. The majority of the studies were conducted in hospitals and included HCWs from West and East Africa. After assessing the quality of the studies, 5 (14.3%) were found to be of high quality, 17 (77.1%) were of moderate quality, and 3 (8.6%) were of low quality. The proportion of HCWs who were fully vaccinated against hepatitis B varied widely, ranging from 0.8% in Rwanda to 72.0% in Libya. The overall pooled full vaccination coverage among HCWs in Africa was 24.7%. Subgroup analyses showed significant variation in vaccination coverage among HCWs in different regions of Africa and Asia, with the highest coverage in North Africa and the lowest in Central and East Africa.
Conclusions: Healthcare workers (HCWs) are at higher risk of infection with Hepatitis B virus (HBV) compared to individuals who do not work in hospitals, with frequencies of infection up to 4 times higher. HBV can be transmitted between patients and HCWs, as well as between HCWs and their relatives, contributing to the ongoing chain of transmission.
المراجع
1. Banatvala, J., Van Damme, P. and Jangu Banatvala, . Hepatitis B vaccine -do we need boosters?
2. Chen, Ding-Shinn. Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B. (2009) Journal of Hepatology. 50(4); 805-816.
3. Singhal, Varsha., Bora, Dhrubajyoti., Singh, Sarman. and Singh, Hepatitis B in Health Care Workers: Indian Scenario. (2009) J Lab Physicians. 1(02); 041-048.
4. Alter, Miriam. Epidemiology of hepatitis B in Europe and worldwide. (2003) Journal of Hepatology. 39; 64-69.
5. Kundi, Michael. New hepatitis B vaccine formulated with an improved adjuvant system. (2007) Expert Review of Vaccines. 6(2); 133-140.
6. Komatsu, Haruki., Klenerman, Paul. and Thimme, Robert. Discordance of hepatitis B vaccination policies for healthcare workers between the USA, the UK, and Germany. (2020) Hepatol Res. 50(3); 272-282.
7. Shepard, Colin., Simard, Edgar., Finelli, Lyn., Fiore, Anthony. and Bell, Beth. Hepatitis B Virus Infection: Epidemiology and Vaccination. (2006) Epidemiologic Reviews. 28(1); 112-125.
8. Chien, Yin-Chu., Jan, Chyi-Feng., Kuo, HsuSung., Chen, Chien-Jen., Chien-, Jen. and Chen, . Nationwide Hepatitis B Vaccination Program in Taiwan: Effectiveness in the 20 Years After It Was Launched. (2006) Epidemiologic Reviews. 28(1); 126-135.
9. Keating, Gillian., Noble, Stuart., Averhoff, F., Belloni, C., Goldwater, P. and Hall, A. Recombinant Hepatitis B Vaccine (Engerix-B ®) A Review of its Immunogenicity and Protective Efficacy Against Hepatitis B.
10. Chen, Gluud., Chen, Wendong., Gluud, Christian., Cochrane, Hepato-Biliary., Group, Ml, Gonzalez., Ml, Ferraz., Pm, Oliveira., Vm, Figueiredo., Vl, Kemp., Filho, Castelo., Benhamou, Thibault, Bochet., Martino, Di., Caumes, ., Hammond, ., Gw, Hammond. and Mitsui, Vaccines for preventing hepatitis B in health-care workers. (2005)
11. Burnett, Rosemary., Dramowski, Angela., Amponsah-Dacosta, Edina., Catharina Meyer, Johanna., Joyce, ., Wiysonge, Charles. and Cooper, Sara. Increasing hepatitis B vaccination coverage of healthcare workers — global lessons for South Africa. (2021) Current Opinion in Immunology. 71; 6-12.
12. Auta, Asa., Adewuyi, Emmanuel., Kureh, Gbednet., Onoviran, Nguavese. and Adeloye, Davies. Hepatitis B vaccination coverage among health-care workers in Africa: A systematic review and meta-analysis. (2018) Vaccine. 36(32); 4851-4860.
13. Ropero, Alba., Carolina, M. and Andrus, Jon. Progress in vaccination against hepatitis B in the Americas.
14. Simard, Edgar., Miller, Jeremy., George, Prethibha., Wasley, Annemarie., Alter, Miriam., Bell, Beth., Finelli, Lyn. and Drph, Hepatitis B Vaccination Coverage Levels Among Healthcare Workers in the United States, 2002-2003. (2007) Infect. Control Hosp. Epidemiol. 28(7); 783-790.
15. Zanetti, Alessandro., Van Damme, Pierre. and Shouval, Daniel. The global impact of vaccination against hepatitis B: A historical overview. (2008) Vaccine. 26(49); 6266-6273.
16. Malewezi, B., Omer, S. B., Mwagomba, B., & Araru, T. (2016). Protecting health workers from nosocomial Hepatitis B infections: A review of strategies and challenges for implementation of Hepatitis B vaccination among health workers in SubSaharan Africa. Journal of epidemiology and global health, 6(4), 229-241.
17. Puro, V., De Carli, G., Cicalini, S., Soldani, F., Balslev, U., Begovac, J., ... & Ippolito, G. (2005). European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus. Eurosurveillance, 10(10), 11-12.
18. Azami, M., Ahmadi, M. R. H., & Sayehmiri, K. (2017). Hepatitis B vaccination efficacy in Iranian healthcare workers: a meta-analysis study. Hepatitis monthly, 17(1).
19. A'zami, M., Nikpey, S., Pakzad, I., & Sayehmiri, K. (2016). Effects of immunization to hepatitis B vaccine in Iranian health staff: a systematic review and meta-analysis study. Koomesh, 17(4), 789795.
20. Alter, M. J. (2003). Epidemiology and prevention of hepatitis B. In Seminars in liver disease (Vol. 23, No. 01, pp. 039-046). Copyright© 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.:+ 1 (212) 584-4662.
21. Gossner, C. M., Severi, E., Danielsson, N., Hutin, Y., & Coulombier, D. (2015). Changing hepatitis, A epidemiology in the European Union: new challenges and opportunities. Eurosurveillance, 20(16), 21101.
22. Hadler, S. C. (1990). Hepatitis B virus infection and health care workers. Vaccine, 8, S24S28.
23. Rischitelli, G., Harris, J., McCauley, L., Gershon, R., & Guidotti, T. (2001). The risk of acquiring hepatitis B or C among public safety workers: a systematic review. American journal of preventive medicine, 20(4), 299-306.
24. Lesmana, L. A., Leung, N. W. Y., Mahachai, V., Phiet, P. H., Suh, D. J., Yao, G., & Zhuang, H. (2006). Hepatitis B: overview of the burden of disease in the Asia‐Pacific region. Liver International, 26(S2), 3-10.
25. Rich, J. D., Ching, C. G., Lally, M. A., Gaitanis, M. M., Schwartzapfel, B., Charuvastra, A., ... & Flanigan, T. P. (2003). A review of the case for hepatitis B vaccination of high-risk adults. The American journal of medicine, 114(4), 316-318.
26. Kashyap, B., Tiwari, U., & Prakash, A. (2018). Hepatitis B virus transmission and health care workers: epidemiology, pathogenesis and diagnosis. Indian Journal of Medical Specialities, 9(1), 30-35.
