Unusual cause of recurrent Pneumothorax caused by Pulmonary Meningothelial-Like Nodule: Peer review
DOI:
https://doi.org/10.59992/IJSR.2025.v4n7p5Keywords:
Immunohistochemistry, Progesterone receptor, CD56, VATS, Bullectomy, Pulmonary meningothelial-like nodule, Recurrent pneumothoraxAbstract
Recurrent pneumothorax, which frequently results from underlying bullous disease, infections, or other lung pathology, can present serious diagnostic and treatment issues. We report the case of a 38-year-old woman with recurrent right-sided pneumothorax. Following VATS bullectomy a pulmonary meningothelial-like nodule (PMLN) was discovered in the resected specimen. Progesterone receptor (PR) positivity and patchy CD56 staining were among the immunohistochemistry (IHC) results; HMB45, MNF, and oestrogen receptor (ER) were negative. Our case emphasises the value of thorough pathological examination in determining uncommon reasons for recurrent pneumothorax and the therapeutic ramifications of such.
References
[1] Chan JK, Chan AC. 64 cases of pulmonary meningothelial-like nodules were studied clinicopathologically. 21(8):937-946; Am J Surge Pathol. 1997.
[2] A study of five cases with meningothelial-like lung nodules was conducted by Katzenstein AL, Sale SR, and Green E. 1983; 14(7):654-659; Hum Pathol.
[3] Travis WD, Nicholson AG, Brambilla E, Burke AP, and Marx A. WHO Classification of Heart, Pleura, Thymus, and Lung Tumours. Fourth edition. IARC, Lyon, 2015.
[4] Management of spontaneous pneumothorax. Clin Chest Med. 2013;34(4):711-728; Rivera JA, Mehta AC, Wahidi MM.
[5] Churchill Livingstone, Philadelphia, 2004. Churg A, Myers JL, Tazelaar HD, Wright JL. Pulmonary Pathology, 2nd ed.
[6] Saraf K, Devine KD, and Thirumala S. Meningothelial-like nodules in the lungs: An uncommon condition linked to pneumothorax. E246–E249 in J Thorac Dis. 2015;7(8).
[7] Marchiori E, D'Ippolito G, Zanetti G, et al. HRCT results for pulmonary meningothelial-like nodules. Pneumol. J Bras. 2008;34(10):769-772.
[8] Travis WD, Koss MN, and Colby TV. lower respiratory tract tumours. Tumour Pathology Atlas. third series. Armed Forces Institute of Pathology, Washington, DC, 2001.
[9] Terrasi AM, Pelosi G, Fraggetta F, et al. Immunohistochemical proof that visceral pleura mesothelium is the source of meningothelial-like lung nodules. 21(6):579-587; Am J Surg Pathol. 1997.
[10] Hormonal receptor positivity in pulmonary meningothelial-like nodules: Is there evidence of hormonal pathogenesis? Gupta R, Sinha S, Jindal A. 2020;37(3):262-266; Lung India.
[11] Thorax, 2006;61(6):527-535; Johnson SR. Pulmonary consequences in lymphangioleiomyomatosis.
[12] Moran CA, Suster S. Lung nodules that resemble meningothelial cells: Histologic, immunohistochemical, and ultrastructural characteristics. 21(1):99-102 in Am J Surg Pathol. 1997.
[13] Wilson RW, Pathria MN, Kirejczyk W, et al. A recent finding is the correlation between diffuse pulmonary fibrosis and meningothelial-like nodules. 21(5):563-567; Am J Surg Pathol. 1997.
[14] Glazer M, Biran I, Hirshberg B, and Kramer MR. One uncommon cause of haemoptysis is metastasised lung tumours. 198–202 in Respiration, 67(2), 2000.
[15] Henske EP, Moss J, Reddy TL, Travis WD, Taveira-Dasilva AM. Lymphangioleiomyomatosis and other uncommon cystic lung disorders. 33(2):283-295 in Clin Chest Med. (2012).
[16] Douglas WW, Myers JL, Aubry MC, et al. One underappreciated cause of numerous pulmonary nodules is primary pulmonary meningothelial-like nodules. 387-390 in Arch Pathol Lab Med. 2007;131(3).