Advancements in Optical Technologies for Medical Imaging and Diagnosis

Authors

  • Mohamed M. Mohsen Author
  • Moftah A. Hussain Author
  • Khalid S. Mustafa Author
  • Mohammed T. Mostafa Author

DOI:

https://doi.org/10.59992/IJSR.2023.v2n10p5

Keywords:

Biomedical Optics, Optical Devices, Light Sources, Laser Sensors, Absorption Spectroscopy, Polarization Sensing

Abstract

Biomedical optics has emerged as a dynamic field encompassing a range of optical devices and technologies, including light sources, lasers, sensors, optical fibers, and optical processing principles. Its impact on medical engineering and clinical applications has been profound, leading to advancements in laboratory practices, optical fibers, biosensing, imaging, radiation grading, absorption spectroscopy, and polarization sensing. This article examines the historical progression of biomedical optics, highlighting its contributions to medical imaging and diagnosis. It focuses particularly on computed tomography, fluorescence imaging, optical molecular imaging, spectroscopy, near-infrared tomography, and optical coherence techniques. Biomedical optics' development has transformed medical science by enabling non-invasive diagnosis, improving treatment planning, and enabling specific therapy. The positive outcomes of these advancements underscore the significance of biomedical optics in promoting progress in the field of medicine. The paper discusses optical technologies and their clinical implications, including spectroscopy, near-infrared tomography, optical coherence tomography, computed tomography, fluorescence imaging, and molecular imaging.

Author Biographies

  • Mohamed M. Mohsen

    Dept. of Biomedical Engineering, University of Tobruk, Libya

  • Moftah A. Hussain

    Dept. of Biomedical Engineering, University of Tobruk, Libya

  • Khalid S. Mustafa

    Dept. of Laboratory Medicine, University of Tobruk, Libya

  • Mohammed T. Mostafa

    Dept. of Laboratory Medicine, University of Tobruk, Libya

References

1. Evan, P., Stater., Magdalena, Skubal., Ryo, Tamura., Jan, Grimm. (2019). The Present and Future of Optical Imaging Technologies in the Clinic: Diagnosis and Therapy. Doi: 10.1007/7355_2019_84

2. Marco, Ferrari., Karl, H., Norris., Michael, G., Sowa. (2012). Guest editorial: Medical near-infrared spectroscopy 35 years after the discovery. Journal of Near Infrared Spectroscopy, Doi: 10.1255/JNIRS.982

3. Claude, A., Piantadosi. (2007). Early development of near-infrared spectroscopy at Duke University, Journal of Biomedical Optics, Doi: 10.1117/1.2804925

4. Takafumi, Hamaoka., Kevin, K., McCully. (2019). Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism. Journal of Physiological Sciences,

Doi: 10.1007/S12576-019-00697-2

5. Johanna, Paulsson. (2014). Time of Flight Spectroscopy of Photon Migration in Turbid Media.

6. Nicholas, R., Trefiak., Jack, A., Barnes., Fiona, Rask., Daniel, G., Courtney., Richard, Walford., Runkai, Li., Richard, D., Oleschuk., Hans-Peter, Loock. (2005). Absorption Measurements in Microfluidic Devices Using Ring-Down Spectroscopy. Doi: 10.1117/12.629756

7. K., Ajito., Masahito, Nakamura., T., Tajima., Yuko, Ueno. (2017). Terahertz Spectroscopy Methods and Instrumentation. Doi: 10.1016/B978-0-12-409547-2.12092-X

8. Amira, C., Padilla-Jiménez., William, Ortiz-Rivera., Carlos, Rios-Velazquez., Iris, Vazquez-Ayala., Samuel, P., Hernández-Rivera. (2014). Detection and discrimination of microorganisms on various substrates with quantum cascade laser spectroscopy. Optical Engineering, Doi: 10.1117/1.OE.53.6.061611

9. Francesco, Banfi., Claudio, Giannetti., Gabriele, Ferrini. (2014). A multimodal approach to time-resolved optical spectroscopy for biomolecular detection.

Doi: 10.1109/LO.2014.6886367

10. Irving, J., Bigio., Judith, R., Mourant., Gerrit, Los. (1999). Elastic-scattering spectroscopy for quantitative measurement of chemotherapy and PDT drug concentrations in vivo. Doi: 10.1117/12.336840

11. Zeinab, Hajjarian., Seemantini, K., Nadkarni. (2020). Tutorial on laser speckle rheology: technology, applications, and opportunities. Journal of Biomedical Optics, Doi: 10.1117/1.JBO.25.5.050801

12. Jhao, Ming, Yu., Liang, Yu, Chen., Min, Cheng, Pan., Ya, Fen, Hsu., Min, Chun, Pan. (2015). Implementation of 3D prostrate ring-scanning mechanism for NIR diffuse optical imaging phantom validation. Proceedings of SPIE,

Doi: 10.1117/12.2080282

13. Hideyuki, Shinzawa., Kimie, Awa., Yukihiro, Ozaki., Hidetoshi, Sato. (2009). Near-Infrared Imaging Analysis of Cellulose Tablets by a Band Position Shift. Applied Spectroscopy, Doi: 10.1366/000370209788964584

14. Zhen, Yuan., Huabei, Jiang. (2013). Diffuse Optical Tomography for Brain Imaging: Theory. Doi: 10.1007/978-1-4614-4978-2_4

15. Chun, Yang., Zhiguo, Shi. (2019). Research in Breast Cancer Imaging Diagnosis Based on Regularized LightGBM. Doi: 10.1007/978-981-15-1925-3_35

16. Michel, Herranz., Álvaro, Ruibal. (2012). Optical imaging in breast cancer diagnosis: the next evolution, Journal of Oncology, Doi: 10.1155/2012/863747

17. Nioka, S., Miwa, M., Orel, S., Shnall, M., Haida, M., Zhao, S., & Chance, B. (1994). Optical imaging of human breast cancer. Oxygen Transport to Tissue XVI, 171-179.

18. Ken, Y., Foo., Kelsey, M., Kennedy., Renate, R., Zilkens., Wes, M., Allen., Qi, Fang., Rowan, W., Sanderson., James, D., Anstie., Benjamin, F., Dessauvagie., Bruce, Latham., Christobel, Saunders., Lixin, Chin., Brendan, F., Kennedy. (2021). Optical palpation for tumor margin assessment in breast-conserving surgery, Biomedical Optics Express, Doi: 10.1364/BOE.415888

19. Maximilian, Eisel., Stephan, Ströbl., Thomas, Pongratz., Herbert, Stepp., Adrian, Rühm., Ronald, Sroka. (2018). Investigation of optical properties of dissected and homogenized biological tissue. Journal of Biomedical Optics,

Doi: 10.1117/1.JBO.23.9.091418

20. Venugopal, Vivek, and Xavier Intes. "Recent advances in optical mammography." Current Medical Imaging 8.3 (2012): 244-259

21. C. H. Schmitz, D. P. Klemer, R. Hardin, M. S. Katz, Y. Pei, H. L. Graber, M. B. Levin, R. D. Levina, N. A. Franco, W. B. Solomon, and R. L. Barbour, "Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements," Applied optics 44, 2140-2153 (2005).

22. Xin, Gao., Binlin, Wu. (2019). Breast cancer diagnosis using fluorescence spectroscopy with dual-wavelength excitation and machine learning.

Doi: 10.1117/12.2509147.

23. Intes, Xavier. "Time-domain optical mammography SoftScan: Initial Results1." Academic radiology 12.8 (2005): 934-947.

24. B. Chance, Z. Zhuang, C. UnAh, C. Alter, and L. Lipton, "Cognition-activated low-frequency modulation of light absorption in human brain," Proceedings of the National Academy of Sciences of the United States of America 90, 3770-3774 (1993).

25. Sergio, Fantini., Blaise, deB., Frederick., Angelo, Sassaroli. (2018). Perspective: Prospects of non-invasive sensing of the human brain with diffuse optical imaging. Doi: 10.1063/1.5038571

26. Matthew, B., Applegate., Raeef, Istfan., Samuel, Spink., Anup, Tank., Darren, Roblyer. (2020). Recent advances in high-speed diffuse optical imaging in biomedicine. Doi: 10.1063/1.5139647

27. E. Watanabe, A. Maki, F. Kawaguchi, K. Takashiro, Y. Yamashita, H. Koizumi, and Y. Mayanagi, "Non-invasive assessment of language dominance with near-infrared spectroscopic mapping," Neurosci Lett 256, 49-52 (1998).

28. B. W. Zeff, B. R. White, H. Dehghani, B. L. Schlaggar, and J. P. Culver, "Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography," Proceedings of the National Academy of Sciences of the United States of America 104, 12169-12174 (2007).

29. G. A. Millikan, "Experiments on Muscle Haemoglobin in vivo; The Instantaneous Measurement of Muscle Metabolism," Proceedings of the Royal Society of London B: Biological Sciences 123, 218-241 (1937).

30. T. Hamaoka, K. K. McCully, V. Quaresima, K. Yamamoto, and B. Chance, "Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans," Journal of Biomedical Optics 12, 062105 (2007).

31. J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nature medicine 1, 970-972 (1995).

32. Z. Yaqoob, J. Wu, E. J. McDowell, X. Heng, and C. Yang, "Methods and application areas of endoscopic optical coherence tomography," J Biomed Opt 11, 063001 (2006).

33. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Optics Express 11, 2183-2189 (2003).

34. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Optics letters 28, 2067-2069 (2003).

35. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Optics Express 11, 889-894 (2003).

36. J. Walther, M. Gaertner, P. Cimalla, A. Burkhardt, L. Kirsten, S. Meissner, and E. Koch, "Optical coherence tomography in biomedical research," Anal Bioanal Chem 400, 2721-2743 (2011).

37. M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Arch Ophthalmol 113, 325-332 (1995).

38. M. E. Brezinski, G. J. Tearney, B. E. Bouma, S. A. Boppart, M. R. Hee, E. A. Swanson, J. F. Southern, and J. G. Fujimoto, "Imaging of coronary artery microstructure (in vitro) with optical coherence tomography," The American journal of cardiology 77, 92-93 (1996).

39. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest Endosc 51, 474-479 (2000).

40. J. Welzel, C. Reinhardt, E. Lankenau, C. Winter, and H. H. Wolff, "Changes in function and morphology of normal human skin: evaluation using optical coherence tomography," Br J Dermatol 150, 220-225 (2004).

41. L. S. de Melo, R. E. de Araujo, A. Z. Freitas, D. Zezell, N. D. Vieira, J. Girkin, A. Hall, M. T. Carvalho, and A. S. Gomes, "Evaluation of enamel dental restoration interface by optical coherence tomography," J Biomed Opt 10, 064027 (2005).

42. M. J. Manyak, N. D. Gladkova, J. H. Makari, A. M. Schwartz, E. V. Zagaynova, L. Zolfaghari, J. M. Zara, R. Iksanov, and F. I. Feldchtein, "Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography," Journal of Endourology 19, 570-574 (2005).

43. 165. S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski, and J. G. Fujimoto, "High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: feasibility for laparoscopic-based imaging," British journal of obstetrics and gynaecology 106, 1071-1077 (1999).

44. C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102, 217-229 (1995).

45. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature medicine 7, 502-507 (2001).

46. M. R. Hee, C. R. Baumal, C. A. Puliafito, J. S. Duker, E. Reichel, J. R. Wilkins, J. G. Coker, J. S. Schuman, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103, 1260-1270 (1996).

47. N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Optics Express 12, 367-376 (2004).

48. B. Povazay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, "Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients," J Biomed Opt 12, 041211 (2007).

49. Z. Chen, T. E. Milner, D. Dave, and J. S. Nelson, "Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media," Optics letters 22, 64-66 (1997).

50. R. Bhindi, S. M. Munir, and K. M. Channon, "Images in cardiovascular medicine. Optical coherence tomography in the setting of an acute anterior myocardial infarction," Circulation 116, e366-367 (2007).

51. I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," Journal of the American College of Cardiology 39, 604-609 (2002).

52. I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).

53. C. Xu, J. M. Schmitt, S. G. Carlier, and R. Virmani, "Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography," J Biomed Opt 13, 034003 (2008).

54. J. A. Evans, J. M. Poneros, B. E. Bouma, J. Bressner, E. F. Halpern, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, N. S. Nishioka, and G. J. Tearney, "Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus," Clin Gastroenterol H 4, 38-43 (2006).

55. Y. Chen, A. D. Aguirre, P. L. Hsiung, S. Desai, P. R. Herz, M. Pedrosa, Q. Huang, M. Figueiredo, S. W. Huang, A. Koski, J. M. Schmitt, J. G. Fujimoto, and H. Mashimo, "Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology," Endoscopy 39, 599-605 (2007).

56. S. P. Lerner, A. C. Goh, N. J. Tresser, and S. S. Shen, "Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer," Urology 72, 133-137 (2008).

57. R. M. Cothren, M. V. Sivak, J. VanDam, R. E. Petras, M. Fitzmaurice, J. M. Crawford, J. Wu, J. F. Brennan, R. P. Rava, R. Manoharan, and M. S. Feld, "Detection of dysplasia at colonoscopy using laser-induced fluorescence: A blinded study," Gastrointest Endosc 44, 168-176 (1996).

58. T. Desmettre, J. M. Devoisselle, and S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Survey of ophthalmology 45, 15-27 (2000).

59. D. Roblyer, R. A. Schwarz, and R. Richards-Kortum, "Fluorescence Spectroscopy," in Handbook of Biomedical Optics, D. A. Boas, C. Pitris, and N. Ramanujam, eds. (CRC Press, Boca Raton, FL, 2011), pp. 217-232.

60. R. J. Antcliff, M. R. Stanford, D. S. Chauhan, E. M. Graham, D. J. Spalton, J. S. Shilling, T. J. Ffytche, and J. Marshall, "Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis," Ophthalmology 107, 593-599 (2000).

Downloads

Published

2023-10-15

Issue

Section

Articles

How to Cite

Advancements in Optical Technologies for Medical Imaging and Diagnosis. (2023). The International Journal for Scientific Research, 2(10). https://doi.org/10.59992/IJSR.2023.v2n10p5