Growth Performances and Serum Biochemical Response of Broiler Chickens Fed on Diet Supplemented with Cyproheptadine as Substitute Growth Promoters

Authors

  • Afrah A. Habeeb Author

DOI:

https://doi.org/10.59992/IJSR.2023.v2n5p1

Keywords:

Cyproheptidine, Broiler

Abstract

The aim of our study is to know the effect of adding cyproheptidine as a feed additive (growth promoter) to the broiler diet. Sixty birds (Ross breed) one day old were been grouped randomly into two groups: a treatment group and a control group, and the chicks were housing and feeding for 49 days (from 1/11 – 19/12/2022). and measure some serum biochemical parameter and growth performance.

The result showed significantly affected (p<0.05) by the treatment group throughout the production period (1-49) days, an increase in body weight, Live body weight gain, Food intake, and weight of abdominal fat, heart, and leg, all other carcass parameters. The serum content of creatinine tends to drop (0.91 mg/dl) while the urea content tends to increase (1.30 mg/dl) in the treatment group. Cyprohptadine was significantly affected (p<0.05) on the serum protein content in the treatment group (2.12 g/dl) than the control group (2.84 g/dl) and there was no significant effect of cyproheptadine in serum contents of (ALAT) and (ASAT), decreased serum content of Cholesterol compared than the control group. From these results, Cyproheptadine is an effective and well-tolerated appetite stimulant in the broiler. So, it can be used to increase the weight of broilers in a shorter period of time than usual.

Author Biography

  • Afrah A. Habeeb

    Technical Institute of Al-Dewaniyah, AL-Furat AL-Awsat Technical
    University (ATU), Iraq

References

[1] Laurence LB, John SL, Keith LP. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. 11th ed. New York: McGraw‑Hill; 2002. p. 313-4.

[2] United States Pharmacopoeia XXII, 1990.

[3] Norris CR, Boothe DM, Esparza T, Gray C, Ragsdale M.: Disposition of cyproheptadine in cats after intravenous or oral administration of a single dose. Am J Vet Res. 1998 Jan;59(1):79–81.

[4] Carol R. Reinero, Kendra C. Decile, Jenni R. Byerly.(2005).Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma. American veterinary medical association journals. Vol.66. No.7.

[5] Epifanio M, Marostica PC, Mattiello R, Feix L, Nejedlo R, Fischer GB, et al. A randomized, double‑blind, placebo‑controlled trial of cyproheptadine for appetite stimulation in cystic fibrosis. J Pediatr (Rio J) 2012; 88:155‑60.

[6] Harrison ME et al.: Use of cyproheptadine to stimulate appetite and body weight gain: a systematic review. Appetite, (2019).

[7] Harrison ME, Norris ML, Robinson A, Spettigue W, Morrissey M, Isserlin L (2019). "Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review". Appetite. 137: 62–72.

[8] Norris CR, Boothe DM, Esparza T, Gray C, Ragsdale M. Disposition of cyproheptadine in cats after intravenous or oral administration of a single dose. (1998). American Journal of Veterinary Research, 59(1):79-81.

[9] M. Tiwaskar: Perception, approach and management of loss of appetite: a cross-sectional, questionnaire-based physician survey. J Assoc Physicians India. (2020).

[10] Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C (2007): Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. J Pharmacol Sci. Feb;103(2):201-6.

[11] Jiang H, Chen R, Wang H, Pu H: Interaction of cyproheptadine hydrochloride with human serum albumin using spectroscopy and molecular modeling methods. Luminescence. 2013; 28(2): 244-52.

[12] Valérie Bertrand, Nathalie Massy, Nancy Vegas , Valérie Gras , Christel Chalouhi, Marie-Pierre Tavolacci, Véronique Abadi. Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. (2021) PMC. Sep 29; 9:712413.

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Published

2023-05-15

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How to Cite

Growth Performances and Serum Biochemical Response of Broiler Chickens Fed on Diet Supplemented with Cyproheptadine as Substitute Growth Promoters. (2023). The International Journal for Scientific Research, 2(5). https://doi.org/10.59992/IJSR.2023.v2n5p1